kaspmedПрикаспийский вестник медицины и фармацииTitle2712-8164ФГБОУ ВО Астраханский ГМУ Минздрава России10.17021/2712-8164-2024-1-14-22kaspmed-13Research ArticleСтатьиПоиск мультитаргетных веществ с антимикробным эффектом – перспективное направление современной фармацевтической наукиSearching for multi-target substances with anti-microbial effect – promising direction modern pharmaceutical scienceСтариковаА. А.StarikovaA. A.

Старикова Алла Андреевна - старший преподаватель кафедры фундаментальной химии.

Астрахань

Alla A. Starikova - Senior Lecturer of the Department, Astrakhan State Medical University.

Astrakhan

alhimik.83@mail.ruМережкинаД. В.MerezhkinaD. V.

Мережкина Дарья Владимировна - аспирант.

Волгоград

Dar'ya V. Merezhkina - postgraduate student, Volgograd State Medical University.

Volgograd

merezhkinad@mail.ruОзеровА. А.OzerovA. A.

Озеров Александр Александрович - доктор химических наук, профессор, заведующий кафедрой фармацевтической и токсикологической химии.

Волгоград

Alexandr A. Ozerov - Dr. Sci. (Chem.), Professor, Head of the Department, Volgograd State Medical University.

Volgograd

prof_ozerov@yahoo.comАстраханский государственный медицинский университетРоссияAstrakhan State Medical UniversityRussian FederationВолгоградский государственный медицинский университетРоссияVolgograd State Medical UniversityRussian Federation202411032025511422Copyright © Старикова А.А., Мережкина Д.В., Озеров А.А., 20252025Старикова А.А., Мережкина Д.В., Озеров А.А.Starikova A.A., Merezhkina D.V., Ozerov A.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.kaspmed.ru/jour/article/view/13

Представлен обзор литературных данных о принципах создания мультитаргетных препаратов и механизмах их действия. Проведен анализ результатов изучения антимикробной активности производных хиназолинона, проявляющих мультитаргетное действие в отношении бактерий группы ESKAPE (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa и Enterobacter). Поиск веществ, способных оказывать воздействие на несколько мишеней в бактериальной клетке, станет способом решения проблемы резистентности патогенов к используемым в современной медицинской практике антимикробным средствам.

The article provides a review of literature data on the principles of creating multi-targeted drugs and their mechanisms of action, and analyses the results of studying the antimicrobial activity of quinazolinone derivatives that exhibit multi-targeted effects against bacteria of the ESKAPE group (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa and Enterobacter). The search for substances that can affect several targets in a bacterial cell will be a way to solve the problem of pathogen resistance to antimicrobial agents used in modern medical practice.

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The authors declare that there are no conflicts of interest present.