Selection of the optimal gel base of the wound healing agent by evaluating the mucoadhesive properties
https://doi.org/10.17021/2712-8164-2025-2-28-33
Abstract
When developing wound healing agents, it is necessary to take into account the strength of mucoadhesion and the time of their retention at the application site, since these properties determine the release time of the drug and the effectiveness of the drug. Goal. Selection of a gel base with high rates of mucoadhesion. Materials and methods. 5 model samples of gels made using potentially promising gelling agents with a high degree of mucoadhesion were selected as objects of research: chitosan, sodium alginate, carbopol, methylcellulose, sodium carboxymethylcellulose. To study mucoadhesion, the separation force of gel compositions and the retention time at the application site were determined. Results. As a result of the conducted research, a composition was selected that is able to maintain its structure longer and remain at the application site, ensuring a long-term release of the active component. Conclusion. In the course of the conducted research, the choice of a promising basis for creating a wound-healing gel was substantiated. Based on the data obtained, carbopol was selected as the optimal gel-forming agent.
About the Authors
S. V. Rytchenkov
Astrakhan State Medical University, Astrakhan, Russia
Россия
Россия
Sergey V. Rytchenkov, Cand. Sci. (Pharm.), Senior Lecturer
V. Yu. Rytchenkova
Astrakhan State Medical University, Astrakhan, Russia
Россия
Россия
Victoria Yu. Rytchenkova, Assistant
S. V. Poroyskiy
Astrakhan State Medical University, Astrakhan, Russia
Россия
Россия
Sergey V. Poroyskiy, Doc. Sci. (Med.), Associate Professor, Head of the Department
M. K. Makalatia
Astrakhan State Medical University, Astrakhan, Russia
Россия
Россия
Maria K. Makalatia, student
D. S. Kapizova
Astrakhan State Medical University, Astrakhan, Russia
Россия
Россия
Diana S. Kapizova, student
References
1. Kharenko E. A., Larionova N. I., Demina N. B. Mucoadhesive dosage forms (review). Khimikofarmatsevticheskiy zhurnal = Chemical and Pharmaceutical Journal. 2009; 43 (4): 21–29 (In Russ.).
2. Inagamov S. Ya., Mukhamedzhanova M. Yu., Mukhamedov G. I. Polycomplex gels based on sodium carboxymethylcellulose – new prolongators of medicines. Khimiya rastitelnogo syrya = Chemistry of plant raw materials. 2011; 4 (2): 51–56 (In Russ.).
3. Bakhrushina E. O., Mikhel I. B., Pyzhov V. S., Demina N. B., Krasnyuk (Jr.) I. I., Krasnyuk I. I. In situ development of an intranasal system based on chitosan formate. = Bulletin of Experimental Biology and Medicine. 2022; 174 (9): 2–6 (In Russ.).
4. Shaikh T. R., Garland M. J., Woolfson A.D. Mucoadhesive drug delivery systems. Journal of pharmacy and Bioallied Sciences. 2011; 3: 89–100.
5. Kamskaya V. E. Chitosan: structure, properties and use. Scientific review. Biologicheskie nauki = Biological Sciences. 2016; 6: 36–42 (In Russ.).
6. Yusova A. A., Gusev I. V., Lipatova I. M. Properties of hydrogels based on mixtures of sodium alginate with other polysaccharides of natural origin. Khimiya rastitelnogo syrya = Chemistry of vegetable raw materials. 2014; 4: 59–66 (In Russ.).
7. Safitri F. I., Nawangsari D., Febrina D. Overview: Application of Carbopol 940 in Gel. Proceedings of the International Conference on Health and Medical Sciences (AHMS 2020). Atlantis Press; 2021.
8. Fazliev S. A., Aminov S. N. Technology of obtaining a hemostatic gel “lagoden” based on carbopol. Farmatsiya i farmakologiya = Pharmacy and pharmacology. 2016; 4 (6): 44–53 (In Russ.).
9. Denisova M. N., Budaeva V. V., Minaev K. M. Sodium-carboxymethylcellulose as the main component of polysaccharide reagents (review). Polzunovskiy vestnik = Polzunovsky Bulletin. 2016; 1 (4): 5–9 (In Russ.).
10. Kholnazarov B. A., Turaev H. H., Nazarov Y. E. Synthesis of hydrogels based on starch and sodiumcarboxymethylcellulose biomaterials. Universum: khimiya i biologiya = Universum: chemistry and Biology. 2020; 10 (76): 57–60 (In Russ.).
11. Santuryan Yu. G., Elokhovsky V. Y., Vlasova E. N., Panarin E. F. Investigation of physico-chemical properties of hydrogels based on cellulose methyl ester. Zhurnal prikladnoy khimii = Journal of Applied Chemistry. 2017; 90 (2): 231–235 (In Russ.).
12. Rytchenkov S. V., Poroyskiy S. V., Stepanova E. F., Tatarenko-Kozmina T. Y., Pleten A. P. Pharmaceutical development of an adhesive gel based on a biodegradable natural complex. Voprosy biologicheskoy, meditsinskoy i farmatsevticheskoy khimii = Issues of biological, medical and pharmaceutical chemistry. 2024; 27 (5): 23–30 (In Russ.).
13. Kharenko E. A., Larionova N. I., Demina N. B. Mucoadhesive dosage forms: a quantitative assessment of the interaction of films made of synthetic and natural polymers with mucous tissue. Khimiko-farmatsevticheskiy zhurnal = Chemical and Pharmaceutical Journal. 2008; 42 (7): 17–24 (In Russ.).
14. Stepanova E. F., Kovtun E. V., Bunyatyan N. D., Monib M. I. Dadu, Privalov I. M., Pleten A. P. Study and selection of optimal rheological characteristics of piracetam gel compositions for intranasal use. Rossiyskiy bioterapevticheskiy zhurnal = Russian Biotherapeutic Journal. 2024; 23 (3): 78–85 (In Russ.).
15. Palvinsky A. G., Bakhrushina E. O., Kholina P. A., Krasnyuk I. I., Biopharmaceutical study of dental gel berberine bisulfate. Voprosy biologicheskoy, meditsinskoy i farmatsevticheskoy khimii = Issues of biological, medical and pharmaceutical chemistry. 2022; 25 (3): 10–14 (In Russ.).
Review
For citations:
Rytchenkov S.V., Rytchenkova V.Yu., Poroyskiy S.V., Makalatia M.K., Kapizova D.S. Selection of the optimal gel base of the wound healing agent by evaluating the mucoadhesive properties. Title. 2025;6(2):28-33. (In Russ.) https://doi.org/10.17021/2712-8164-2025-2-28-33
Views:
207
JATS XML
Email this article 