Clinical diagnostic value IL-1β levels in children with ulcer disease didum and erosive gastroduodenitis
https://doi.org/10.17021/2712-8164-2024-1-41-47
Abstract
Today, duodenal ulcer and chronic gastroduodenitis represent a serious problem in clinical medicine. According to modern medical reviews, despite the undoubted commonality of pathogenetic mechanisms, deviation in the implementation of duodenal ulcer or erosive gastroduodenitis is largely dictated by a genetically predetermined variant of the cytokine response. Purpose of the study: to determine the clinical significance of changes in IL-1β levels in blood serum and gastric secretions in children with duodenal ulcer and erosive gastroduodenitis. Results. A unidirectional statistically significant increase in the level of secretory and serum IL-1β relative to control values during the period of exacerbation of duodenal ulcer and erosive gastroduodenitis was determined. During the period of remission, a statistically significant decrease in IL-1β levels occurs: in the blood serum to control values, in gastric secretions – with elevated levels remaining. A statistically significant prevalence of serum IL-1β levels in patients with erosive gastroduodenitis relative to the indicators detected in patients with duodenal ulcer was established. Conclusion: it is advisable to monitor the level of IL-1β in the blood serum to clarify the phase of the inflammatory process in patients with a mild clinical picture.
About the Authors
S. D. Ikhsanov
Alexandro-Mariinskaya Regional Clinical Hospital
Россия
Россия
Sabit D. Ikhsanov - endoscopist, Alexandro-Mariinskaya Regional Clinical Hospital.
Astrakhan
D. F. Sergienko
Astrakhan State Medical University
Россия
Россия
Diana F. Sergienko - Dr. Sci. (Med.), Professor, Professor of the Department, Astrakhan State Medical University.
Astrakhan
N. A. Polyakova
Children's City Polyclinic No. 1
Россия
Россия
Natal'ya A. Polyakova - Cand. Sci. (Med.), Deputy Chief Physician, Children's City Polyclinic No. 1.
Astrakhan
O. V. Anisimova
Children's City Polyclinic No. 1
Россия
Россия
Ol'ga V. Anisimova - Head of Department, Children's City Polyclinic No. 1.
Astrakhan
O. V. Zaporozhskaya
Children's City Polyclinic No. 1
Россия
Россия
Ol'ga V. Zaporozhskaya - Head of the Department, Children's City Polyclinic No. 1.
Astrakhan
N. A. Il'enkova
Krasnoyarsk State Medical University
Россия
Россия
Natal'ya A. Il'enkova - Dr. Sci. (Med.), Professor, Head of Department of University Clinic, Head of Department, Krasnoyarsk State Medical University, Chief freelance pulmonologist of the Ministry of Health of the Krasnoyarsk region.
Krasnoyarsk
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Review
For citations:
Ikhsanov S.D., Sergienko D.F., Polyakova N.A., Anisimova O.V., Zaporozhskaya O.V., Il'enkova N.A. Clinical diagnostic value IL-1β levels in children with ulcer disease didum and erosive gastroduodenitis. Title. 2024;5(1):41-47. (In Russ.) https://doi.org/10.17021/2712-8164-2024-1-41-47
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