Methods for determining antibiotics as components of pharmaceutical substances and dosage forms, as well as biological fluids and environmental objects

Abstract

Today, the practice of pharmaceutical, biopharmaceutical analysis and environmental monitoring involves the use of a wide range of physical, physicochemical and microbiological methods for determining antibiotics in pharmaceutical substances, dosage forms, biological samples, and environmental objects. However, the need to develop new and improve the applied methods for determining the quantitative content of the active ingredient in an antibiotic is critical. Increasing the accuracy, sensitivity, and selectivity of methods is presented as a way to increase the effectiveness and safety of the antibacterial agents used. A review of the literature data allows us to note the continuity of the work of researchers aimed at improving the characteristics of existing analysis methods. A distinctive feature of the modern direction of analytical practice is its interface with information technological support of both a professional level and publicly available items (smartphones), which helps to increase the speed of quality control, as well as the convenience of its implementation in various conditions, including laboratories that do not have expensive laboratory equipment.