Biopharmaceutical studies on the selection of the composition of a pharmaceutical composition with wound-healing action

According to the World Health Organization Global Oral Health Report 2022, the number of people suffering from oral diseases worldwide is estimated at almost 3.5 billion. Caries of permanent teeth affects 2 billion people worldwide and 514 million children have caries of replaceable teeth. Pharmacotherapy of periodontal diseases involves an integrated approach that combines the use of drugs with multidirectional effects. Gel is the most promising dosage form for a dental drug. In this regard, it is of interest to develop a soft dosage form for the treatment of diseases of the oral mucosa with a complex effect. Objective. Conducting comparative biopharmaceutical studies of 8 gel compositions to select the optimal composition of the wound healing gel. Materials and methods. The main active ingredients in the samples are tizol, L-arginine and peony extract; the following were used as bases: a mixture of polyethylene glycol 400 and polyethylene glycol 1500, vaseline-lanolin base, a mixture of lanolin and lecithin, carbopol, methylcellulose, sodium carboxymethylcellulose, sodium alginate and chitosan. The testing was carried out according to the main indicators of gel quality. The first stage was to determine the thermal and colloidal stability of the presented samples. Then, the
homogeneity of the gel compositions was assessed. The final stage was to study the degree of release of active components into the gelatin gel. Results. As a result of the conducted research, samples were selected that meet the requirements of regulatory documentation for the studied quality indicators. Conclusion. It was established that compositions based on carbopol and sodium alginate are the most promising for further research.

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