Searching for multi-target substances with anti-microbial effect – promising direction modern pharmaceutical science
https://doi.org/10.17021/2712-8164-2024-1-14-22
Abstract
The article provides a review of literature data on the principles of creating multi-targeted drugs and their mechanisms of action, and analyses the results of studying the antimicrobial activity of quinazolinone derivatives that exhibit multi-targeted effects against bacteria of the ESKAPE group (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa and Enterobacter). The search for substances that can affect several targets in a bacterial cell will be a way to solve the problem of pathogen resistance to antimicrobial agents used in modern medical practice.
About the Authors
A. A. Starikova
Astrakhan State Medical University
Россия
Россия
Alla A. Starikova - Senior Lecturer of the Department, Astrakhan State Medical University.
Astrakhan
D. V. Merezhkina
Volgograd State Medical University
Россия
Россия
Dar'ya V. Merezhkina - postgraduate student, Volgograd State Medical University.
Volgograd
A. A. Ozerov
Volgograd State Medical University
Россия
Россия
Alexandr A. Ozerov - Dr. Sci. (Chem.), Professor, Head of the Department, Volgograd State Medical University.
Volgograd
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Review
For citations:
Starikova A.A., Merezhkina D.V., Ozerov A.A. Searching for multi-target substances with anti-microbial effect – promising direction modern pharmaceutical science. Title. 2024;5(1):14-22. (In Russ.) https://doi.org/10.17021/2712-8164-2024-1-14-22
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